The authors created a consensus genome-scale model of CHO cell metabolism with 1,766 genes and 6,663 reactions describing metabolism and protein production during cell growth. Cell line-specific models for CHO-K1, CHO-S, and CHO-DG44 cells were also created and the integration of -omics data revealed amino acid auxotrophy bases in various cell lines.
Users will be able to visualize CHO cell mRNA expression data either from published DNA-microarray or RNA-Seq experiments via JBrowse. The visualized data will enable users to easily obtain gene expression levels and compare gene expression levels among different conditions.
August 19, 2016
CHOmine, the InterMine site for CHO and Chinese hamster, went online on August 11, 2016 at https://chomine.boku.ac.at/. CHOmine collects and integrates publicly available Chinese hamster and CHO data, where different datasets are connected to provide user-friendly access. Currently, users are asked to test the site and to provide feedback (impressions, comments, issues, and suggestions for improvements) to Matthias.Gerstl@acib.at or Nicole.Borth@boku.ac.at.
CHO Epigenomic Data
April 14, 2016
A new database of epigenomic information (cho-epigenome.boku.ac.at) for 6 CHO cell lines has been created by Dr. Nicole Borth's group. A link to this database has been added to CHOgenome.org's Data webpage. The epigenomic database website hosts genome sequences for 6 cell lines, SNPs, structural variants, full genome methylation data, and batch culture histone modification data. The manuscript describing the acquisition and analysis of the data can be found here.
Search the RefSeq Chinese Hamster and CHO-K1 assemblies
BLAST sequences against Chinese Hamster or CHO-K1 genomes
View the annotated RefSeq Chinese Hamster or CHO-K1 genomes
Search the 2-D gel and shotgun datasets
Useful Chinese Hamster publications and files
CH Genome Viewer
View the chromosome-sorted Chinese Hamster genome
Mammalian Systems Biotechnology Workshop
August 11 - August 12, 2016
This workshop will bring together globally eminent experts actively working in the Mammalian Systems Biotechnology field, in order to share and discuss state-of-the-art developments and their industrial applications.
The 251st ACS National Meeting & Exposition in San Diego, CA will convene from March 13 - 17, 2016 and the BIOT division will focus on the exchange of information among academic and industrial researchers regarding technology utilizing life-based systems to produce useful products and services.