2012 LEGACY SITE:
CHO Genome Community
The Chinese hamster (Cricetulus griseus) ovary (CHO) cell line was first isolated by Puck (J. Exp. Med. 1958; 108: 259-271) more than 50 years ago. Currently, CHO cells are the most important cell line for production of biopharmaceuticals. The 2011 CHO-produced biopharmaceutical sales totaled nearly US$ 60 billion, more than half the 2011 biopharmaceutical sales total of US$ 113 billion (La Merie Publishing. "R&D Pipeline News." PipelineReview.com. 25 Apr. 2012.). CHO cells offer tremendous promise for production of vaccines as well as in their ongoing critical role as a transfection host for understanding gene function. Despite the scientific and economic importance of this cell line, there is no publicly available genome sequence information for CHO cells.
A Resource for CHO cell genomics
Based on an open source model, the mission of the CHOgenome.org User Group is to share genome-scale information on Chinese Hamster Ovary cells to the international scientific community.
This website, currently hosted at the University of Delaware, is dedicated to hosting data and resources to support the international community working with CHO cells.
We are building the infrastructure to support genome sequencing activities through an international not-for-profit community-based effort.
|For more information, feel free to contact:||Kelvin Lee (Univ. Delaware; KHL at udel dot edu)
Nicole Borth (BOKU; nicole dot borth at boku dot ac dot at)
Michael Betenbaugh (Johns Hopkins Univ.; beten at jhu dot edu)
What is planned for CHOgenome.org?
|photo courtesy of Nicole Borth|
Currently we are developing the framework for:
- Hosting the latest update of the CHO genome
- Providing genome browsing and annotation tools
- Linking to other genomic databases
Future plans include:
- Hosting transcriptomic, proteomic, and metabolomic data
- Developing a user forum and other community features
- Providing support for the development of user tools, such as siRNA or microRNA screens